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KETOCONAZOLE This is not a medical report. Its information is presented by non medical personnel. Any drug program should be discussed with your physician or endocronologist! About Ketoconazole: Ketoconazole is used to treat fungal infections. It binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall. With its high affinity for fungal cell membranes, Ketoconazole is currently the world's #1 prescribed ingredient for treating dandruff (an uninflamed form of seborrhoeic dermatitis) and is available under the brand name Nizoral. Ketoconazole is also used as a topical agent to treat other skin and scalp disorders such as ringworm, athlete's foot, fungal infections of the fingernails, toenails, etc. Ketoconazole in pill form is used for systemic treatment of infection. Oral ketoconazole is less often prescribed than in past years, because the newer drugs, such as itraconazole and fluconazole that are less likely to upset liver function. According to Science Daily, ketoconazole also function as a weak antiandrogen. This compound can reduce levels of androgen from both the testicles and adrenal glands. Brand Name: Nizoral. Side effects: Ketoconazole is well tolerated when used in the shampoo preparations in accordance to the instructions. Most commonly reported side effects associated with ketoconazole based shampoos are dryness of the scalp and mild irritations. However, when used internally as a pill, ketoconazole can suppress hormone production, including testosterone, especially at high doses over a long time. Ketoconazole must be used cautiously if you have a history of liver disease. Hepatitis is the most dangerous side effect of this drug. Additive liver toxicity can occur if this drug is not used properly and with caution under the supervision of your doctor. Some people may experience nausea, vomiting, diarrhea, and headache while using this drug internally. Ketoconazole should not be taken with the antihistimine Seldane (also known as terfenadine) as they may lead to irregular hearbeats that could be fatal. Topical application: Use topically as directed. No more than twice weekly. Vendors
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