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TOPIC
NF-Kappa-B

NF-KappaB: a molecule which encourages the transformation of healthy cells to cancerous ones.

NF-kappa-B  & Stress – frizz 06/30/03

Forum discussion
http://www.hairsite4.com/dc/dcboard.php?az=show_topic&forum=
8&topic_id=6244&mode=full

Forum Abstract
Could NF-kappa-B be a stress induced response...ie.certain people w/certain gene more likely to become stressed.....NF-KappaB produced as result:

NF-kappa-B: a transcription factor that is upregulated by stress signals such as ultraviolet light and free radicals. It is negatively regulated by I-kappa-B protein.

nfkappab inhibitor – Calcitriol – Frizz 6/30/03

Forum discussion
http://www.hairsite4.com/dc/dcboard.php?az=show_topic&forum
=8&topic_id=6320&mode=full

Forum Abstract
http://people.bu.edu/gilmore/nf-kb/inhibitors/#top

nfkappab inhibitor: Inhibitor Molecule Detected Effect References 
Benfotiamine (thiamine derivative) DNA binding Hammes et al., 2003 
Calcitriol (1a,25-dihydroxyvitamine D3) DNA binding Harant et al., 1998 , and guess what....dovonex is another thing i use( calcipotriene...synthetic vitamin d3) anyone know the difference b/t calcipotriene & Calcitriol, i was thinkin about the results i've had so far...and think fluridil has a lot to do with it...but the super strong capasacin topical i use could have been more of a key component than i thought.

Topical Feverfew as a strong NFKappaB inhibitor: The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase - Flow-Bee 7/25/03

Forum discussion
http://www.hairsite4.com/dc/dcboard.php?az=
show_topic&forum=8&topic_id=8525&mode=full

Forum Abstract
I am also taking it internally for auto-immune regulation. I am using the .7% Parthinolide standardization which has been investigated and published.

Chem Biol. 2001 Aug;8(8) 59-66. Related Articles, Links


The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.

Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.

BACKGROUND: Biologically active natural products continue to be useful in the exploration and control of intracellular signaling processes. For example, the sesquiterpene lactone parthenolide from the anti-inflammatory medicinal herb Feverfew (Tanacetum parthenium) appears to inhibit the pro-inflammatory signaling pathway. Parthenolide's direct molecular target, however, remains unknown. We set out to identify the molecular mechanisms of parthenolide's anti-inflammatory activity. RESULTS: A parthenolide affinity reagent was synthesized and shown to bind directly to and inhibit IkappaB kinase beta (IKKbeta), the kinase subunit known to play a critical role in cytokine-mediated signaling. Mutation of cysteine 179 in the activation loop of IKKbeta abolished sensitivity towards parthenolide. Moreover, we showed that parthenolide's in vitro and in vivo anti-inflammatory activity is mediated through the alpha-methylene gamma-lactone moiety shared by other sesquiterpene lactones. CONCLUSIONS: In recent years, the multi-subunit IKK complex has been shown to be responsible for cytokine-mediated stimulation of genes involved in inflammation and as such represents an attractive target for pharmaceutical intervention. Our finding that parthenolide targets this kinase complex provides a possible molecular basis for the anti-inflammatory properties of parthenolide. In addition, these results may be useful in the development of additional anti-inflammatory agents.

PMID: 11514225

I also use topical:
Phenytonin, GS, Acetyl-L-Carnitine, GTE, Tumeric (a natural proteosome inhibitor).

Note that this is for general discussion only, info presented here
may or may not be accurate. Please consult your doctor before
you use anything for hair loss

        
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