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Flutamide

Summary of Flutamide related posts in the forum

Flutamide: Quote from Dr. Sintov's study "New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice. An in vitro diffusion study of flutamide gel using hairless mouse skin demonstrated the beneficial effect of the vehicle composition in comparison with a hydroalcoholic solution or a gel containing no penetration enhancer. It is therefore suggested that this topical composition containing flutamide or finasteride may effectively result in regression of male-pattern baldness." - read below for details.

Other Flutamide related posts
Flutamide - making flutamide
Flutamide - side effects

flutamide gel

From: iap
Date: 11 Nov 2000
Time: 19:20:35
Remote Name: 128.193.168.150

Comments

http://www.bgu.ac.il/IAR/Amnon-3.htm

Re: flutamide gel..it regrows 150 hair /cm2...!!!!!!!its the cure !!!! and they even tested theres no systemic absorption...what else are we looking for ?????

From: even better than HT !!!!!!! (HT is 50 hair/cm2)
Date: 12 Nov 2000
Time: 05:08:06
Remote Name: 212.1.133.21

Comments

Re: flutamide gel..it PUT 47% OF HAIR BACK IN ANAGEN MODE !!!!

From:
Date: 12 Nov 2000
Time: 05:12:55
Remote Name: 212.1.133.21

flutamide gel

From: iap
Date: 12 Nov 2000
Time: 11:47:35
Remote Name: 128.193.168.150

Comments

flutamide works

From:
Date: 12 Nov 2000
Time: 14:37:43
Remote Name: 24.43.13.90

Comments

Contact Dr. Sintov I

From: Pavlo
Date: 13 Nov 2000
Time: 10:18:50
Remote Name: 62.0.68.151

Comments

Hi I have called today Dr. Sintov ,this is the first time i have the chance to speak with the researcher in my own language hebrew. First dr. Sintov say that the experiment which is reported in his publications was done the following way. Grafts were taken from the scalp of an almost totally bald person they were implanden on amouse and a flutamide +the gel was applied to this grafts the result was 150 hairs/cm in regular quality (width etc..). Dr. Sintov says that the problem right now is moving to the phase of human studies cause the gel that is used together with the flutamide should be given to humans during the experiment time under supervision of experts this requres alot of money and he tries to find big company that will help him continue with his experiments.

The university in which Dr. Sintov is working in is called Ben-Gurion Universuity BGU is the intials. The president of this University is called Prof Braverman this guy is totally bald ,he is well known in his attitude that states that academic researh should be done for profits and i told Dr. Sintov to talk to Braverman and ask his help. I also gave him the contact info of Mr. Yoram Titz which is the number 1 expert in israel for raising money and carried out projects Mr. Titz is also Totally bald.

We decided to speak again in aweek or two and to see how we move things forward. By the way Dr. Sintov has heard about Gho.

Bye

Re: Contac Dr. Sintov I

From: maneless
Date: 18 Nov 2000
Time: 18:45:33
Remote Name: 64.12.105.181

Comments

If we have the complete instructions on how to make this flutamide gel then if Dr. Lee will make it that might just solve the problem. BUT Dr. Lee has to make it exactly as it is made in the study - EXACTLY.

If Dr. Lee changes it even a little that will turn it into something else altogether. The flutamide is already available so the real issue then is the vehicle/Gel.

Is there a patent on the Gel? Is Dr. Lee allowed to make the gel? I don't think there's any reason dr. Lee would not be allowed to make the gel unless there's a patent on the gel. But even if there is a patent on the gel if Dr. Lee will pay the patent holder for the right to use the gel then I think dr. Lee would then be allowed to use that gel and he could mix the gel exactly as the Israeli dr did.

We might have something here guys.

It looks like someone may have figured out a way to turn flutmaide into RU58841.

Flutamide Gel – the medical article

From: James Bond
Date: 13 Nov 2000
Time: 21:54:26
Remote Name: 206.133.236.12

Comments

New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice.

Sintov A, Serafimovich S, Gilhar A

Ben-Gurion University of the Negev, The Institutes for Applied Research, PO Box 653, Beer-Sheva, Israel. asintov@bgumail.bgu.ac.il

The purpose of this study was to test the ability of topical formulations of finasteride and flutamide to re-enlarge hair follicles in male-pattern baldness. This was evaluated by an experimental model of human scalp skin graft transplanted onto SCID mice. A comparison was made between formulations containing finasteride and flutamide, and a vehicle formulation in terms of the mean hairs per graft, length, diameter of the shafts, and structures of the growth stages of the hair. Flutamide and finasteride had a significantly higher effect (P<0.05) than the placebo in all the tested parameters, but flutamide demonstrated more hair per graft and longer hair shafts than finasteride (P<0.05). The number of hairs per graft for flutamide and finasteride groups were 1.22+/-0. 47 and 0.88+/-0.95 hairs/0.5 mm2 graft, respectively, versus 0. 35+/-0.6 hairs/graft for vehicle-treated graft. Similarly, hair lengths for flutamide and finasteride were 5.82+/-0.50 and 4.50+/-0. 32 mm, respectively, versus 2.83+/-0.18 mm for the vehicle-treated grafts. An in vitro diffusion study of flutamide gel using hairless mouse skin demonstrated the beneficial effect of the vehicle composition in comparison with a hydroalcoholic solution or a gel containing no penetration enhancer. It is therefore suggested that this topical composition containing flutamide or finasteride may effectively result in regression of male-pattern baldness.

PMID: 10601691, UI: 20070724

Results in 12 days – Think Again

From: Mohawk
Date: 13 Nov 2000
Time: 22:40:50
Remote Name: 204.94.76.115

Comments

Read Sinstov research paper. It very clearly states that within 12 days the mice had hair in angen phase. Again, you will NOT have a full head of hair in 12 days. Even if you were a mouse.

Also there is some confusion regarding hair regrowth. There is nothing wrong with your hair follicles. It is the dht/immune system combination that that binds/attacks your follicles which causes the miniturization. Once the cause is removed/negated your hair immediately begins its normal cycle, length, diameter etc. But it does so progressively, not all at once.

This means that you will NOT have 6 inch terminal, pigmented hairs in the next cycle. But they will start growing towards that.

Take my choking illustration. When someone is choking you, there is nothing wrong with your throat. It's just being restricted. The moment the cause of choking is removed you instantly can begin to breathe again. Same thing with your hair

Again, I advise you to wait for Pavlo. You people sure as hell dont want to be playing junior chemist. Consider this: The 3rd leading cause of death in the USA after heart disease and cancer is... doctor error! July 26, 2000 JAMA issue.

Now if men and women with 10+ years of school are that dangerous what do you think your community college chemist is going to do?

SINTOV GEL PATENT!!

From:
Date: 14 Nov 2000
Time: 00:28:40
Remote Name: 203.166.224.64

Comments

http://164.195.100.11/netacgi/nph-Parser?Sect1=
PTO2&Sect2=HITOFF&p=1&u=/netahtml/search-
bool.html&r=31&f=G&l=50&co1=AND&d=ft00&s1=sintov&
OS=sintov&RS=sintov

Cut and paste this address together in your browser's address field and you'll find the patent for a gel by Sintov. Surely someone can have this custom-compounded with Flutamide and try it out.

DON'T CALL DR. SINTOV

From: Pavlo
Date: 15 Nov 2000
Time: 20:29:16
Remote Name: 62.0.69.35

Comments

Hi POlaese Don't call Dr. Sintov i am already in contact with him and if you call him we will may have the same problem like we have with gho in which we cannot get any info i will contact Dr. sintov next week and i will try to help him move things forward bu if someone will talk to him Dr. Sintov might began behaving like Gho. As for the gel I dontr advise anyone to prepare it on his own cause Dr. Sintov says it might be toxic .

PLEASE DON'T CALL DR. SINTOV BYE

Re: to maneless   - I  AM ANSWERING

From: maneless
Date: 18 Nov 2000
Time: 19:30:39
Remote Name: 64.12.105.181

Comments

The only thing wrong with flutamide is that it gets into the body applied topically. It looks the gel that this Israeli doctor has solved that problem. We need that gel. Oral flutamide grew a full head of hair on me but since it got into my body (taken orally) I had side affects so I had to get off of it. If this gel can get the flutamide into our follicles without the flutamide getting into our bodies - WOW! A bunch of hair with no side affects. It would be the same as RU58841. WOW!

Re: to maneless   - I  AM ANSWERING

From: maneless
Date: 20 Nov 2000
Time: 11:46:01
Remote Name: 152.163.204.9

Comments

They were lumps right under the nipples man. I don't know for sure they would've gotten any bigger but I do not want to take flutamide again unless I'm sure it's not gonna get into my body. I want it in the follicles but not in my body.

The hair was like a crew cut coming in over my whole head. It looked like it looked when I was 16. It had the right color and each strand looked like that thick hair I had before I started losing hair. It was the good hair - the stuff you want.

But I was starting to grow tits man, and I do not want tits on me.

BTW the inability to have sex and the loss of energy feel worse than you would imagine.

BTW#2 I think the hair that was coming in fell out within a few days of me getting off the oral flutamide.

Re: Flutamide – the patent info

From: James Bond
Date: 17 Nov 2000
Time: 22:43:43
Remote Name: 63.10.229.3

Comments

Here is the site with the patent. I have only read the abstract so far and I am unsure if the write up has any good details. I am going back to read it now. If you can't access the site you may need a password. In this case go to the WIPO patent database homepage and enter as guest and then do a search of sintov and click on his baldness patent.

http://l2.espacenet.com/dips/bnsviewer?CY=wo&LG=en&DB=EPD&PN=
9962464&ID=WO+++9962464A1+I+

Full text with a lot of info.

From: James Bond
Date: 17 Nov 2000
Time: 23:04:30
Remote Name: 63.10.229.3

Comments

To all of those interested in flutamide gel this patent is a must read. Use link in above post and click through the multiple pages of the patent.

JB

Flutamide study on women

From: tk421
Date: 17 Nov 2000
Time: 12:36:53
Remote Name: 132.206.197.116

Comments

Read this:

Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial.

Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F

Medical Research Council Group in Molecular Endocrinology, Centre Hospitalier, Universite Laval Research Center, Quebec, Canada.

OBJECTIVE: To compare the clinical efficacy and safety of the pure antiandrogen flutamide and the steroidal derivative spironolactone in the treatment of hirsutism in women. DESIGN: Fifty-three premenopausal women suffering from moderate to severe hirsutism were randomized into two groups and received either flutamide or spironolactone in association with a triphasic oral contraceptive (OC) pill. Hirsutism, acne, seborrhea, alopecia, and side effects were monitored monthly for a treatment period of 9 months and a follow-up after treatment period of 6 months. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. RESULTS: After only 6 months of therapy, flutamide caused a maximal reduction in the hirsutism score to a value within almost normal range; during the same period, spironolactone caused only a 30% reduction of the hirsutism score. Whereas flutamide caused a dramatic (80%) decrease in total acne, seborrhea, and hair loss score after only 3 months of therapy, spironolactone caused only a 50% reduction in acne and seborrhea, with no significant effect on the hair loss score. Four patients in the spironolactone group but only one in the flutamide group stopped the medication because of adverse side effects. CONCLUSION: The present data obtained in a randomized prospective study clearly demonstrate that the pure antiandrogen flutamide is superior to spironolactone in the treatment of female hirsutism and its related androgen-dependent symptoms and signs in women.

Remember that antiandrogen therapy is much more powerful on men, since FPB is far more complex that MPB. And keep in mind that the stuff we will be using is topical. This is looking very good.

Re: Real results from Flutamide

From: maneless
Date: 18 Nov 2000
Time: 19:40:37
Remote Name: 64.12.105.181

Comments

 Dr.Sintov's patent text – under Swiss Espacenet

From: Paul
Date: 18 Nov 2000
Time: 05:21:29
Remote Name: 212.49.235.129

Comments

Good job, James Bond !

I couldn't access the link as there was some prob with my acrobar Reader.

So, I went to the Swiss espacenet, typed flutamide, and in the middle of all, this is what I've found . That guy is serious about it...

TOPICAL COMPOSITION FOR TREATMENT OF BALDNESS Veröffentlichungsnr. (Sek.) WO9962464 Veröffentlichungsdatum : 1999-12-09 Erfinder : GILHAR AMOS (IL); SINTOV AMNON (IL) Anmelder :: TECHNION RES & DEV FOUNDATION (IL); GILHAR AMOS (IL); SINTOV AMNON (IL); UNIV BEN GURION (IL) Originalnummer : WO9962464 Anmeldenummer : WO1999IL00274 19990524 Prioritätsnummer : IL19980124764 19980604 IPC Klassification : A61K7/06 ; A61K31/495 ; A61K31/58 ; A61K31/165 EC Klassification : A61K7/06C14B, A61K7/06C6D3, A61K7/06C14D Korrespondierende Patentschriften

-------------------------------------------------------------------------------- Zusammenfassung --------------------------------------------------------------------------------

The invention provides a topical composition for treatment and/or prevention of male-pattern baldness comprising between about 0.5-10 wt.% of an active ingredient selected from the group consisting of finasteride, flutamide, nilutamide and mixtures thereof, in combination with a pharmaceutically acceptable topical carrier, said topical carrier comprising between 10-80 wt.% alcohol and said composition being devoid of sex-related steroidal active ingredients.

Dr.Sintov's patent text

From: James Bond
Date: 18 Nov 2000
Time: 15:00:29
Remote Name: 63.10.223.158

Comments

If you go to the WIPO homepage and search for Sintov you will get the full 17 pages that detail the exact formulas that he used and give enough information to experiment with your own.

The catch is you have to register to do a WIPO search (only takes a couple of minutes). It is best to just print the whole 17 pages out instead of viewing them in Acrobat.

There is a flutamide formula that is given that uses Methocel E15. I recommend using the Methocel E15 premium grade as opposed to the Ethocel 100 (as used in the finesteride formula). Methocel mimics natural plant gums and is well tolerated by the body. I don't believe that Ethocel is metablolized well by the body if it enters the blood stream (it is basically plastic). It (premium grade) does seem to be fairly benign when taken orally but I don't suggest that anyone injects or absorbs it through the skin. Probably the reason Sintov uses it though is because it is not easily absorbable through the skin into the bloodstream and it holds the finesteride into the skin for a very long time, where it works on the follicle continuously. Still, the thought of plastic skin is a turn off.

Methocel E15 and Ethocel 100 are used as thickening agents (gel if you will) that form a film. Methocel is water soluble and a much more natural molecule.

For anyone that is interested, Aracel 186 is a mixture of glycerol oleate and propylene glycol. It is used as a surfactant(solubilizes water in oil). It is used frequently in the cosmetic industry (for instance typical hair dressing and grooming products that are formulated with oil in water emulsions).

I think the most interesting aspect of this delivery vehicle would be to try different combinations of drug formulas and experiment with the synergistic effects.

In conclusion if you use the exact formula that is detailed for the flutamide you can't go wrong. From there you can experiment with drug dosages. I think the best thing to do is to make up the vehicle separately and just add your own drugs as you go.

If you are wondering about obtaining the chemicals, call your local supplier and check on the availability. I am not sure of the regulations where these two are concerned. I believe DOW manufactures both though.

Contact Dr. Sintov II

From: Pavlo
Date: 20 Nov 2000
Time: 11:36:11
Remote Name: 62.0.72.214

Comments

Hi Today i have contact Dr. Sintov again i gave him tjhe office phone number of mr. yoram titz which is the israeli number 1 expert (not jokking) in money raising.I have also spoken to titz yesterday and told himanout Sintov he was very intersted but wanted to hear things from Sintov himself,I have agreed to speak with sintov next week. As for your questions the mice body didnt reject the human grafts since the mice thAT are used doesnt have immune system,so they are used to preform such kind of experiments i know about an expirement regarding skin aging that was performed by sintovs associate Dr. Gilhar which was performed in the same technique. The disadvantage of these mice is that they should kept isolated cause lack of immune system renders the volnerable to infactions even though they dont live more than afew months ,this maybe answers the second question i belive that the hair grew after not more than 2 months (can be much less) but i will ask sintov this question next week. As for making the gel in private this gel can be toxic and anyone who will use it on his own can suffer avery severe side effects . I am trying to move things forward and to help sintov build a stsrt up that will perform trhe neccessary experiments and will bring this gel to th market (if it is workin ASAP) Bye

Other Flutamide related posts
Flutamide - making flutamide
Flutamide - side effects

        
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