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References
Note that
this is for general discussion only, info presented here
may or may not be accurate. Please consult your doctor
before
you use anything for hair loss
TOPIC
Estrogen & Male Pattern Baldness
New evidence for the beneficial role of estrogen for hair
loss in men and women - 5/25/04. Abstract: Surprisingly,
compared to the vehicle control, the hair shaft elongation
of male front temporal scalp hair follicles was
significantly stimulated by 1-100 nM E2 already as early as
1 d after the start of the organ culture, and this
stimulation became even more pronounced at the end of organ
culture (days 7 and 9).
Types of estrogens (estrone, estradiol, estriol) and
discussion on estrogens and male pattern baldness. 04/05/04
Growing imbalance between testosterone and estrogen in aging
men and its implications for hairloss. McHale 03/19/04
Estrogen
receptor alpha, but not estrogen receptor beta, is involved in
the regulation of the hair follicle cycling as well as the
thickness of epidermis in male mice. – sdm777 7/23/03
Forum
Discussion
http://www.hairsite4.com/dc/dcboard.php?az=
show_mesg&forum=11&topic_id=21987&mesg_id=21989&page=
Forum
Abstract
Estrogen
receptor alpha, but not estrogen receptor beta, is involved in
the regulation of the hair follicle cycling as well as the
thickness of epidermis in male mice. – sdm777 7/23/03
<QUOTE FROM ABOVE LINK>
Estrogen receptor alpha, but not estrogen receptor beta, is
involved in the regulation of the hair follicle cycling as
well as the thickness of epidermis in male mice.
Moverare S, Lindberg MK, Faergemann J, Gustafsson JA, Ohlsson
C.
Department of Internal Medicine (Division of Endocrinology),
Sahlgrenska University Hospital, S-41345 Goteborg, Sweden.
Estrogen is of importance for the regulation of hair growth
and epidermal thickness. The effects of estrogen have
predominantly been studied in females; however, recent studies
demonstrate that estrogen also is critical for males. The aim
of this study was to investigate the relative functional
importance of estrogen receptor alpha and estrogen receptor
beta in the regulation of the hair follicle cycling and
epidermal thickness in male mice. Seven month old transgenic
male mice, lacking estrogen receptor alpha (ERKO), estrogen
receptor beta (BERKO), or both receptors (DERKO), were
orchidectomized and treated for 3 week with 17beta-estradiol
or vehicle. Orchidectomy induced a synchronized anagen phase
of the hair follicles, which was inhibited by 17beta-estradiol
treatment in wild-type and BERKO mice, but not in ERKO and
DERKO mice. Furthermore, 17beta-estradiol treatment increased
the thickness of epidermis in wild-type and BERKO mice, but
not in ERKO and DERKO. This study demonstrates that estrogen
is of importance for the regulation of hair follicle cycling
and epidermal thickness in male mice. The effect on hair
follicle cycling is caused by an estrogen receptor alpha
mediated inhibition of telogen-anagen transition and the
effect of estrogen to increase epidermal thickness is
associated with an estrogen receptor alpha mediated increase
in the proliferative rate of the keratinocytes in the basal
cell layer of the epidermis.
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